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There are several matches for 'extracellular ligand binding protein'.
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1259 matches
showing page 1 of 63
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organism
protein
1)
Homo sapiens
DLL1 - Delta-like
protein
1; Transmembrane
ligand
protein
of NOTCH1, NOTCH2 and NOTCH3 receptors that
binds
the
extracellular
domain (ECD) of Notch receptor in a cis and trans fashion manner. Following transinteraction,
ligand
cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring
ligand
ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor
extracellular
domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain [...]
[a.k.a. XP_005266991.1, R-HSA-162582, DL1]
2)
Homo sapiens
EGFR - Epidermal growth factor receptor; Receptor tyrosine kinase
binding
ligands
of the EGF family and activating several signaling cascades to convert
extracellular
cues into appropriate cellular responses. Known
ligands
include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-
binding
EGF.
Ligand
binding
triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter
proteins
like GRB2 which in turn activates complex downstream signaling cascades. Activates at leas [...]
[a.k.a. 5C8K, NM_001346900, 3G5Y]
3)
Homo sapiens
MST1R - Macrophage-stimulating
protein
receptor alpha chain; Receptor tyrosine kinase that transduces signals from the
extracellular
matrix into the cytoplasm by
binding
to MST1
ligand
. Regulates many physiological processes including cell survival, migration and differentiation.
Ligand
binding
at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by
ligand
, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON lea [...]
[a.k.a. NM_002447.4, XM_011533744, NP_001231866.1]
4)
Homo sapiens
MERTK - Tyrosine-
protein
kinase Mer; Receptor tyrosine kinase that transduces signals from the
extracellular
matrix into the cytoplasm by
binding
to several
ligands
including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis).
Ligand
binding
at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by
ligand
, interacts with GRB2 or PLCG2 and induces phosphorylation [...]
[a.k.a. ENST00000439966, R-HSA-202733, MER]
5)
Homo sapiens
TYRO3 - Tyrosine-
protein
kinase receptor TYRO3; Receptor tyrosine kinase that transduces signals from the
extracellular
matrix into the cytoplasm by
binding
to several
ligands
including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation.
Ligand
binding
at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by
ligand
, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival [...]
[a.k.a. ENSP00000324885, URS0000EAC505, ENST00000559066]
6)
Homo sapiens
AXL - Tyrosine-
protein
kinase receptor UFO; Receptor tyrosine kinase that transduces signals from the
extracellular
matrix into the cytoplasm by
binding
growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation.
Ligand
binding
at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by
ligand
, ALX
binds
and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates [...]
[a.k.a. NP_001265528.1, R-HSA-162582, HPA075217]
7)
Homo sapiens
MAP2K1 - Dual specificity mitogen-activated
protein
kinase kinase 1; Dual specificity
protein
kinase which acts as an essential component of the MAP kinase signal transduction pathway.
Binding
of
extracellular
ligands
such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity
protein
kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]
[a.k.a. XP_016877900, R-HSA-112409, XP_011520085.1]
8)
Homo sapiens
POGLUT1 -
Protein
O-glucosyltransferase 1; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C- X-S-X-P-C. Specifically targets
extracellular
EGF repeats of
protein
such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch
ligand
binding
. Required during early development to promote gastrulation: acts by mediating O-g [...]
[a.k.a. BAD96657.1, AC074271, ENST00000497447]
9)
Homo sapiens
LRP8 - Low-density lipoprotein receptor-related
protein
8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing
ligands
. LRP8 participates in transmitting the
extracellular
Reelin signal to intracellular signaling processes, by
binding
to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brai [...]
[a.k.a. XM_006710882.4, ENST00000335236, R-HSA-388396]
10)
Homo sapiens
RET -
Extracellular
cell-membrane anchored RET cadherin 120 kDa fragment; Receptor tyrosine-
protein
kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon
binding
with glial cell derived neurotrophic factor family
ligands
. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and [...]
[a.k.a. MEN2B, ENSP00000327108, NM_020975]
11)
Homo sapiens
TNK2 - Activated CDC42 kinase 1; Non-receptor tyrosine-
protein
and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces
extracellular
signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through
binding
to epidermal growth factor receptor (EGFR) and clathrin.
Binds
to both poly- and mono-ubiquitin and regulates
ligand
-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting [...]
[a.k.a. 3EQP, 1U46, hsa:10188]
12)
Mus musculus
Dll1 - Dll1-derived cell-associated form; Transmembrane
ligand
protein
of NOTCH1, NOTCH2 and NOTCH3 receptors that
binds
the
extracellular
domain (ECD) of Notch receptor in a cis and trans fashion manner. Following transinteraction,
ligand
cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring
ligand
ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor
extracellular
domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intrace [...]
[a.k.a. XM_011246267, R-MMU-157118, mmu:13388]
13)
Mus musculus
Mst1r - Macrophage-stimulating
protein
receptor alpha chain; Receptor tyrosine kinase that transduces signals from the
extracellular
matrix into the cytoplasm by
binding
to MST1
ligand
. Regulates many physiological processes including cell survival, migration and differentiation.
Ligand
binding
at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by
ligand
, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON lea [...]
[a.k.a. ENSMUST00000195113.1, 19882, XR_379756]
14)
Mus musculus
Mertk - Tyrosine-
protein
kinase Mer; Receptor tyrosine kinase that transduces signals from the
extracellular
matrix into the cytoplasm by
binding
to several
ligands
including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis).
Ligand
binding
at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by
ligand
, interacts with GRB2 or PLCG2 and induces phosphorylation [...]
[a.k.a. Eyk, MER proto-oncogene tyrosine kinase, AAA80222.1]
15)
Mus musculus
Tyro3 - Tyrosine-
protein
kinase receptor TYRO3; Receptor tyrosine kinase that transduces signals from the
extracellular
matrix into the cytoplasm by
binding
to several
ligands
including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation.
Ligand
binding
at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by
ligand
, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival [...]
[a.k.a. AAH66058.1, TK19-2, U23719]
16)
Mus musculus
Egfr - Epidermal growth factor receptor; Receptor tyrosine kinase
binding
ligands
of the EGF family and activating several signaling cascades to convert
extracellular
cues into appropriate cellular responses. Known
ligands
include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF.
Ligand
binding
triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter
proteins
like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]
[a.k.a. R-MMU-157118, R-MMU-8939211, BAB23641.1]
17)
Mus musculus
Axl - Tyrosine-
protein
kinase receptor UFO; Receptor tyrosine kinase that transduces signals from the
extracellular
matrix into the cytoplasm by
binding
growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation.
Ligand
binding
at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by
ligand
, ALX
binds
and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates [...]
[a.k.a. XP_006540055, ENSMUSP00000130577, ENSMUST00000085948.10]
18)
Mus musculus
Map2k1 - Dual specificity mitogen-activated
protein
kinase kinase 1; Dual specificity
protein
kinase which acts as an essential component of the MAP kinase signal transduction pathway.
Binding
of
extracellular
ligands
such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity
protein
kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]
[a.k.a. Map2k1-203, R-MMU-169893, AAH54754.1]
19)
Mus musculus
Poglut1 -
Protein
O-glucosyltransferase 1; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C- X-S-X-P-C. Specifically targets
extracellular
EGF repeats of
protein
such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity). Notch glucosylation does not affect Notch
ligand
binding
(By similarity). Required during early development to promote gas [...]
[a.k.a. ENSMUST00000149704, BAC27475.1, ENSMUST00000148093.1]
20)
Mus musculus
Lrp8 - Low-density lipoprotein receptor-related
protein
8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing
ligands
. LRP8 participates in transmitting the
extracellular
Reelin signal to intracellular signaling processes, by
binding
to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brai [...]
[a.k.a. ENSMUSP00000158682, XM_011240463.2, UPI0005AB9947]
1259 matches
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